Privacy Policy

Privacy Policy


Spectrum Pharmaceuticals, Inc. (“Spectrum”) is committed to respecting your privacy. This Privacy Policy is intended to answer your important questions about our privacy practices, whether you are looking for health information or are seeking to learn from Spectrum to refine your expertise in meeting the needs of your patients.

This Web Site, located at (the “Web Site”), is owned and operated by Spectrum. We recognize the importance of privacy to you and the other users of this Web Site. As a result, we have instituted this Web Site Privacy Policy, which applies only to the operation of this Web Site. Spectrum is providing this notice to explain our online information practices. This Privacy Policy applies only to the use and collection of data collected by us on this Web Site and does not apply to any other data collected by us in any other manner online or off-line.

In general, you may visit our Web Site and view its content while remaining anonymous by not providing any personal information. By using this Web Site, you agree to the terms of this Privacy Policy and, if you provide us your personal information, you consent to the collection, use, and disclosure of your information as described in this Privacy Policy. If you do not agree with this policy, please do not provide us any information and do not use this Web Site.

As used in this Privacy Policy, “we” includes Spectrum and any third-party vendors we hire to assist in the administration of this Web Site and/or the processing or handling of customer information. These vendors are required to maintain the confidentiality of the user information and are prohibited from using it for any purpose other than as described in this Privacy Policy.

Please note that Spectrum’s websites are directed towards users who reside in the United States of America. It is not our intent to gather personally identifiable information from individuals residing outside the U.S. Your access to and use of the website constitutes acceptance of this Privacy Policy and consent to Spectrum’s collection and use of your information as outlined below.

Information Collection and Use

Spectrum may collect non-personally identifiable information about how you use this Web Site using analysis technologies. These analysis technologies may be provided by third parties. Information that might be collected using these technologies includes, for example, the pages you visit on this Web Site, the paths you take within this Web Site, and the length of time that you spend on this Web Site. We use this information in the aggregate in order to better understand how to improve the quality of this Web Site.

As is common among Internet site operators, the operator of this Web Site maintains Web server logs. Web servers automatically identify your computer by its IP address and collect that information in its Web server logs. An IP address is a number that is automatically assigned to your computer by your Internet service provider whenever you log onto the World Wide Web or “surf” the Internet. The Spectrum Web server log collect statistical data that is generated by your computer when it visits this Web Site, such as the type of Web browser and operating system used to access this Web Site, the domain name of your Internet service provider, the date and time you access this Web Site, and the pages you visit. This Web Site uses this non-personally identifying Web server log information for a variety of purposes. Some of these purposes include: system administration; examination of overall traffic trends on this Web Site; troubleshooting; and the collection of broad demographic information about users of this Web Site. No personally identifiable information is contained in these Web server logs. The log files may be purged periodically, in our discretion, to maximize space on the server. In addition to the purposes described above, any information we collect may also be used for analytics purposes (e.g., evaluating site usage patterns, assessing throughput) so that we can gauge the effectiveness of our programs and improve the usefulness of information presented to users. Spectrum is the owner of all information collected on this website.


Like many Web sites, this Web Site also uses a technology called “cookies”. A cookie is a small text file that a Web server gives your browser to store on your computer when you access a Web site. Cookies are capable of storing many types of data and may be placed on your browser by Spectrum. Information gathered from cookies in this way is only used on an aggregate basis. We may also use cookies to store preferences; record session information; develop information about Web Site visitors’ preferences and interests; record past activity at a Web Site in order to provide better service when you return to our Web Site; or customize Web page content based on information you voluntarily provide.

In all cases in which cookies are used, however, Spectrum will not knowingly use the cookie to collect personally identifiable information from this Web Site, unless you voluntarily agree to enter the information. Most Web browsers are set up to accept cookies. Your browser can be set to allow you to control whether you accept cookies, reject cookies, or to notify you each time a cookie is sent to you. If your browser is set to reject cookies, Web sites that are cookie-enabled will not recognize you when you return to the Web site, and some Web site functionality may be lost. The Help section of your browser will tell you how to prevent your browser from accepting cookies. Note, however, that some portions of this Web Site may not work properly if you refuse cookies.

Use of Information

We may collect personally identifying information that you affirmatively provide to us, including, without limitation, your name, address, telephone number, and/or e-mail address and, if you are a physician, your specialty and certain generic patient and practice information.

From time to time, we may use this information to better understand your needs and how we can improve our products and services. When you voluntarily give us your personal contact information, we may use this information to contact you directly.

We may use this information to provide you with information or as otherwise disclosed to you on the registration Web page when you submit your information to us, including, without limitation, receiving announcements, information, and newsletters. In addition, your personally-identifying information may be shared with third parties (i) as required by law, such as when compelled by subpoena or court order, (ii) to protect and defend the rights of Spectrum and its employees, this Web Site, or the users of this Web Site, (iii) as incident to a sale, merger, reorganization, dissolution, bankruptcy, or similar event, (iv) under circumstances we believe reasonably necessary to protect the personal safety of users of Spectrum products, this Web Site, or the public, (v) to complete any transaction initiated by you on this Web Site or to provide services or information to you, or (vi) as is otherwise described in this Privacy Policy. The information you provide will be maintained for a commercially reasonable period of time by Spectrum for administrative, liability, and archival purposes.

We may also disclose the aggregate statistical data that we collect to third parties in order to allow them to measure the effectiveness of our programs and advertisements.

Comments, e-mails, suggestions, or other communications sent by you to us are deemed to be
non-confidential (except with regard to personally identifying information included therein), and we are free to use or distribute them in any way without compensation to the author, sender, or any other party.

We might also merge the information collected through off-line sources with data collected through our Web Site into the same database.


This Web site may contain links to third-party Web sites on the Internet that are not under the control of or maintained by Spectrum. Please recognize that we do not control these third-party Web sites and this Privacy Policy will not apply to those Web sites. Such links do not constitute an endorsement by Spectrum of those other websites, the content displayed therein, or the persons or entities associated therewith. You acknowledge that Spectrum is providing these links to you only as a convenience, and you agree that Spectrum is not responsible for the privacy practices or the content included on third-party Web sites. Your use of these other linked websites is subject to the respective terms of use and privacy policies located on the linked websites.

Security of Data Stored by Spectrum

Spectrum and its third-party providers may employ procedural and technological security measures, consistent with industry practice. Such measures are reasonably designed to protect your personally identifiable information from loss, misuse, unauthorized access, disclosure, alteration or destruction of the information under our direct control. While we make reasonable efforts to ensure the integrity and security of our network and systems, we cannot guarantee that our security measures will prevent third parties from illegally obtaining this information. However, you provide your information to us at your own risk. We cannot guarantee that your data will not be lost, accessed without authorization, disclosed, altered, or destroyed. You should consider any communication that you transmit to Spectrum (such as personally identifiable or other data, questions or answers, comments, or suggestions) as non-confidential and agree that Spectrum shall not be liable or responsible if any information about you is intercepted and used by an unintended recipient.

Sharing and Disclosure

We may provide your personally identifiable information that we collect and the data generated by cookies to our partner entities, and the vendors and service agencies that we may engage to assist us. For example, we may provide your personally identifiable information to an organization in order to complete a service (e.g., send out newsletter e-mails you have requested), to assist us in reviewing the data or to provide marketing or advertising on our behalf. Any organization to which we provide such personally identifiable information is also required to keep your personally identifiable information confidential in accordance with this Privacy Policy.

We will also disclose your personally identifiable information if we reasonably believe we are required to do so by law, regulation, legal process, or other government authority (such as reporting safety information to the Food and Drug Administration); to investigate fraud; to protect your safety or the safety of others; or when we have reason to believe that disclosing this information is necessary to protect our rights or the rights of a third party who may be harmed by your activities.

We will not sell your personally identifiable information to any other company or organization except we may transfer your personally identifiable information to a successor entity upon a merger, consolidation or other corporate reorganization in which Spectrum participates or to a purchaser of all or a portion of Spectrum’s assets. Such successor entity shall be bound by the terms and conditions of this Privacy Policy.


This Web Site is not intended for or designed to attract children under the age of 18. Spectrum uses reasonable efforts and does not knowingly collect, use, or disclose personally identifiable information from children under the age of 18 years old without the consent of a parent or guardian.

International Users

Personal data that you have voluntarily entered electronically is delivered to servers located in the United States. By using this Web Site, you consent to the transfer of this personal and non-personal data and to our use of such personal and non-personal data as outlined in this Privacy Policy.

California Users

We do not disclose your personal information to third parties for the third parties’ direct marketing purposes, as governed by California Civil Code 1798.83.

Access or Correction of Your Personally Identifying Information; Opt Out from Receiving Communications

You may always contact us to remove or update personally identifiable information from our database. To request a copy of your personally identifiable information stored by Spectrum, please send an e-mail containing your request to You must provide your full name, e-mail address, and any other information reasonably requested by Spectrum. You may then correct or delete such information using the procedures specified in the e-mail message.

In addition, if you no longer wish to receive communications from us, you may opt out at any time by notifying us at

Changes to this Privacy Policy

Spectrum may, from time to time in its sole discretion, change or modify this Privacy Policy. Any changes or modification will be effective upon posting of the revisions at  Spectrum may post changes or modifications to referenced policies and guidelines without your approval, and may determine whether and when any such changes apply to you. Your use of this Web Sites or the services following our posting of any changes will constitute your acceptance of such changes. Should you not wish to be bound by the modified Privacy Policy statement, do not use this Web Site or the services.

This Privacy Policy is effective as of November 5, 2018.


Indications and Usage

KHAPZORYTM is a folate analog indicated for:

  • Rescue after high-dose methotrexate therapy in patients with osteosarcoma.
  • Diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination.
  • Treatment of patients with metastatic colorectal cancer in combination with fluorouracil.

Limitations of Use

KHAPZORY is not indicated for the treatment of pernicious anemia and megaloblastic anemia secondary to lack of vitamin B12 because of the risk of progression of neurologic manifestations despite hematologic remission.

Important Safety Information


  • KHAPZORY is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid, or folinic acid.

Warnings and Precautions

  • Increased gastrointestinal toxicities with fluorouracil: Gastrointestinal toxicities, including stomatitis and diarrhea, occur more commonly and may be of greater severity and of prolonged duration. Deaths from severe enterocolitis, diarrhea, and dehydration have occurred in elderly patients receiving weekly d,l-leucovorin and fluorouracil. Do not initiate or continue therapy with KHAPZORY and fluorouracil in patients with symptoms of gastrointestinal toxicity until those symptoms have resolved. Monitor patients with diarrhea until it has resolved as rapid deterioration leading to death can occur.
  • Drug interaction with trimethoprim-sulfamethoxazole: Concomitant use of d,l-leucovorin with trimethoprim-sulfamethoxazole for the acute treatment of Pneumocystis jiroveci pneumonia in patients with HIV infection increased treatment failure and morbidity.

Adverse Reactions

  • The most common adverse reactions (≥20%) in patients receiving high-dose methotrexate therapy with levoleucovorin rescue were stomatitis (38%) and vomiting (38%).
  • The most common adverse reactions (>50%) in patients receiving levoleucovorin in combination with fluorouracil for metastatic colorectal cancer were stomatitis (72%), diarrhea (70%), and nausea (62%).

Drug Interactions

Leucovorin products increase the toxicity of fluorouracil.

Use in Specific Populations

Levoleucovorin is administered in combination with methotrexate or fluorouracil, which can cause embryo-fetal harm. Refer to methotrexate and fluorouracil prescribing information for additional information.

Please click here to see full Prescribing Information for KHAPZORY.


Reporting of Suspected Adverse Reactions

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

This site is intended for U.S. Healthcare Professionals only